Ontology highlight
ABSTRACT:
SUBMITTER: Rosental B
PROVIDER: S-EPMC3269963 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Rosental Benyamin B Brusilovsky Michael M Hadad Uzi U Oz Dafna D Appel Michael Y MY Afergan Fabian F Yossef Rami R Rosenberg Lior Ann LA Aharoni Amir A Cerwenka Adelheid A Campbell Kerry S KS Braiman Alex A Porgador Angel A
Journal of immunology (Baltimore, Md. : 1950) 20111021 11
NK cells play an important role in the early immune response to cancer. The NKp44 activating receptor is the only natural cytotoxicity receptor that is expressed exclusively by primate NK cells, yet its cellular ligands remain largely unknown. Proliferating cell nuclear Ag (PCNA) is overexpressed in cancer cells. In this study, we show that the NKp44 receptor recognizes PCNA. Their interaction inhibits NK cell function through NKp44/ITIM. The physical interaction of NKp44 and PCNA is enabled by ...[more]