Ontology highlight
ABSTRACT:
SUBMITTER: Widemann BC
PROVIDER: S-EPMC3271115 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Widemann Brigitte C BC Arceci Robert J RJ Jayaprakash Nalini N Fox Elizabeth E Zannikos Peter P Goodspeed Wendy W Goodwin Anne A Wright John J JJ Blaney Susan M SM Adamson Peter C PC Balis Frank M FM
Pediatric blood & cancer 20100921 2
<h4>Background</h4>The objectives of this trial were to define the toxicity profile, dose, pharmacokinetics, and pharmacodynamics of the farnesyl transferase (FTase) inhibitor, tipifarnib, in children and adolescents with hematological malignancies.<h4>Procedure</h4>Tipifarnib was administered twice daily for 21 days, repeated every 28 days starting at a dose of 300 mg/m(2) /dose. Pharmacokinetic sampling was performed for 36 hr after the first dose and leukemic blasts were collected pre-treatme ...[more]