Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC3271591 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ma Xianjue X Huang Jiuhong J Yang Lixia L Yang Yang Y Li Wenzhe W Xue Lei L
Cell research 20110816 2
Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further delineate the Egr-triggered cell death pathway, we performed a genetic screen to identify dominant modifiers of the Egr-induced cell death phenotype. Here we report that Egr elicit ...[more]