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Monomer-on-monomer (MoM) Mitsunobu reaction: facile purification utilizing surface-initiated sequestration.

ABSTRACT: A monomer-on-monomer (MoM) Mitsunobu reaction utilizing norbornenyl-tagged (Nb-tagged) reagents is reported, whereby purification was rapidly achieved by employing ring-opening metathesis polymerization, which was initiated by any of three methods utilizing Grubbs catalyst: (i) free catalyst in solution, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.

SUBMITTER: Maity PK

PROVIDER: S-EPMC3271942 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Monomer-on-monomer (MoM) Mitsunobu reaction: facile purification utilizing surface-initiated sequestration.

Maity Pradip K PK Rolfe Alan A Samarakoon Thiwanka B TB Faisal Saqib S Kurtz Ryan D RD Long Toby R TR Schätz Alexander A Flynn Daniel L DL Grass Robert N RN Stark Wendelin J WJ Reiser Oliver O Hanson Paul R PR

Organic letters 20101201 1

A monomer-on-monomer (MoM) Mitsunobu reaction utilizing norbornenyl-tagged (Nb-tagged) reagents is reported, whereby purification was rapidly achieved by employing ring-opening metathesis polymerization, which was initiated by any of three methods utilizing Grubbs catalyst: (i) free catalyst in solution, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles. ...[more]

PMID: 21121636

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