Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC3272018 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Jin Yan Y Liu Zheng Z Cao Wei W Ma Xinying X Fan Yihui Y Yu Yang Y Bai Jing J Chen Feng F Rosales Jesusa J Lee Ki-Young KY Fu Songbin S
PloS one 20120203 2
Double minute chromosomes or double minutes (DMs) are cytogenetic hallmarks of extrachromosomal genomic amplification and play a critical role in tumorigenesis. Amplified copies of oncogenes in DMs have been associated with increased growth and survival of cancer cells but DNA sequences in DMs which are mostly non-coding remain to be characterized. Following sequencing and bioinformatics analyses, we have found 5 novel matrix attachment regions (MARs) in a 682 kb DM in the human ovarian cancer c ...[more]