Ontology highlight
ABSTRACT:
SUBMITTER: Lane DP
PROVIDER: S-EPMC3272259 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Lane David P DP Madhumalar Arumugam A Lee Alison P AP Tay Boon-Hui BH Verma Chandra C Brenner Sydney S Venkatesh Byrappa B
Cell cycle (Georgetown, Tex.) 20111215 24
Analysis of the genome of the elephant shark (Callorhinchus milii), a member of the cartilaginous fishes (Class Chondrichthyes), reveals that it encodes all three members of the p53 gene family, p53, p63 and p73, each with clear homology to the equivalent gene in bony vertebrates (Class Osteichthyes). Thus, the gene duplication events that lead to the presence of three family members in the vertebrates dates to before the Silurian era. It also encodes Mdm2 and Mdm4 genes but does not encode the ...[more]