Ontology highlight
ABSTRACT:
SUBMITTER: Carmona-Fontaine C
PROVIDER: S-EPMC3272547 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Carmona-Fontaine Carlos C Theveneau Eric E Tzekou Apostolia A Tada Masazumi M Woods Mae M Page Karen M KM Parsons Maddy M Lambris John D JD Mayor Roberto R
Developmental cell 20111124 6
Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are ...[more]