Ontology highlight
ABSTRACT:
SUBMITTER: Byun JS
PROVIDER: S-EPMC3272570 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nature communications 20120117
Transcription is a multi-stage process that coordinates several steps within the transcription cycle including chromatin reorganization, RNA polymerase II recruitment, initiation, promoter clearance and elongation. Recent advances have identified the super elongation complex, containing the eleven-nineteen lysine-rich leukaemia (ELL) protein, as a key regulator of transcriptional elongation. Here we show that ELL has a diverse and kinetically distinct role before its assembly into the super elon ...[more]