Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds N
PROVIDER: S-EPMC3273378 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Reynolds Nicola N Salmon-Divon Mali M Dvinge Heidi H Hynes-Allen Antony A Balasooriya Gayan G Leaford Donna D Behrens Axel A Bertone Paul P Hendrich Brian B
The EMBO journal 20111202 3
Pluripotent cells possess the ability to differentiate into any cell type. Commitment to differentiate into specific lineages requires strict control of gene expression to coordinate the downregulation of lineage inappropriate genes while enabling the expression of lineage-specific genes. The nucleosome remodelling and deacetylation complex (NuRD) is required for lineage commitment of pluripotent cells; however, the mechanism through which it exerts this effect has not been defined. Here, we sho ...[more]