Ontology highlight
ABSTRACT:
SUBMITTER: Henckel A
PROVIDER: S-EPMC3273379 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Henckel Amandine A Chebli Karim K Kota Satya K SK Arnaud Philippe P Feil Robert R
The EMBO journal 20111125 3
Genomic imprinting in mammals is controlled by DNA methylation imprints that are acquired in the gametes, at essential sequence elements called 'imprinting control regions' (ICRs). What signals paternal imprint acquisition in male germ cells remains unknown. To address this question, we explored histone methylation at ICRs in mouse primordial germ cells (PGCs). By 13.5 days post coitum (d.p.c.), H3 lysine-9 and H4 lysine-20 trimethylation are depleted from ICRs in male (and female) PGCs, indicat ...[more]