Ontology highlight
ABSTRACT:
SUBMITTER: Seifert R
PROVIDER: S-EPMC3273670 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Seifert Roland R Lushington Gerald H GH Mou Tung-Chung TC Gille Andreas A Sprang Stephen R SR
Trends in pharmacological sciences 20111117 2
Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different expression patterns. Studies with mAC gene knockout mice provide evidence for the notion that AC isoforms play distinct (patho)physiological roles. Consequently, there is substantial interest in the development of isoform-selective mAC inhibitors. Here, we review the current literature on mAC inhibitors. Structurally diverse inhibitors targeting the catalytic site and allosteric sites (e.g. the diterpene site ...[more]