Regulatory mechanisms in bone following mechanical loading.
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ABSTRACT:
SUBMITTER: Mantila Roosa SM
PROVIDER: S-EPMC3273934 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Regulatory mechanisms in bone following mechanical loading.
Mantila Roosa Sara M SM Turner Charles H CH Liu Yunlong Y
Gene regulation and systems biology 20120117
Bone responds with increased bone formation to mechanical loading, and the time course of bone formation after initiating mechanical loading is well characterized. However, the regulatory activities governing the loading-dependent changes in gene expression are not well understood. The goal of this study was to identify the time-dependent regulatory mechanisms that governed mechanical loading-induced gene expression in bone using a predictive bioinformatics algorithm. A standard model for bone l ...[more]
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