Ontology highlight
ABSTRACT:
SUBMITTER: Gordon LR
PROVIDER: S-EPMC3274363 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20120301 5
In zebrafish, the MuSK receptor initiates neuromuscular synapse formation by restricting presynaptic growth cones and postsynaptic acetylcholine receptors (AChRs) to the center of skeletal muscle cells. Increasing evidence suggests a role for Wnts in this process, yet how muscle cells respond to Wnt signals is unclear. Here, we show that in vivo, wnt11r and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at ...[more]