Ontology highlight
ABSTRACT:
SUBMITTER: O'Hara GA
PROVIDER: S-EPMC3274376 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
O'Hara Geraldine A GA Duncan Christopher J A CJ Ewer Katie J KJ Collins Katharine A KA Elias Sean C SC Halstead Fenella D FD Goodman Anna L AL Edwards Nick J NJ Reyes-Sandoval Arturo A Bird Prudence P Rowland Rosalind R Sheehy Susanne H SH Poulton Ian D ID Hutchings Claire C Todryk Stephen S Andrews Laura L Folgori Antonella A Berrie Eleanor E Moyle Sarah S Nicosia Alfredo A Colloca Stefano S Cortese Riccardo R Siani Loredana L Lawrie Alison M AM Gilbert Sarah C SC Hill Adrian V S AV
The Journal of infectious diseases 20120124 5
<h4>Background</h4>Vaccine development in human Plasmodium falciparum malaria has been hampered by the exceptionally high levels of CD8(+) T cells required for efficacy. Use of potently immunogenic human adenoviruses as vaccine vectors could overcome this problem, but these are limited by preexisting immunity to human adenoviruses.<h4>Methods</h4>From 2007 to 2010, we undertook a phase I dose and route finding study of a new malaria vaccine, a replication-incompetent chimpanzee adenovirus 63 (Ch ...[more]