Ontology highlight
ABSTRACT:
SUBMITTER: Kirby CA
PROVIDER: S-EPMC3274384 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Kirby Christina A CA Cheung Atwood A Fazal Aleem A Shultz Michael D MD Stams Travis T
Acta crystallographica. Section F, Structural biology and crystallization communications 20120121 Pt 2
The crystal structures of tankyrase 1 (TNKS1) in complex with two small-molecule inhibitors, PJ34 and XAV939, both at 2.0 Å resolution, are reported. The structure of TNKS1 in complex with PJ34 reveals two molecules of PJ34 bound in the NAD(+) donor pocket. One molecule is in the nicotinamide portion of the pocket, as previously observed in other PARP structures, while the second molecule is bound in the adenosine portion of the pocket. Additionally, unlike the unliganded crystallization system, ...[more]