Ontology highlight
ABSTRACT:
SUBMITTER: Chen F
PROVIDER: S-EPMC3274634 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Chen Fei F Liu Zhugong Z Wu Wenhui W Rozo Cristina C Bowdridge Scott S Millman Ariel A Van Rooijen Nico N Urban Joseph F JF Wynn Thomas A TA Gause William C WC
Nature medicine 20120115 2
Helminths induce potent T helper 2 (TH2)-type immune responses that can mediate worm expulsion, but the role of this response in controlling the acute tissue damage caused by migrating multicellular parasites through vital tissues remains uncertain. We used a helminth infection model in which parasitic nematode larvae migrate transiently through the lung, resulting in hemorrhage and inflammation. We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 r ...[more]