Novel neuropathologic findings in the Haddad syndrome.
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ABSTRACT:
SUBMITTER: Tomycz ND
PROVIDER: S-EPMC3274774 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Novel neuropathologic findings in the Haddad syndrome.
Tomycz Nestor D ND Haynes Robin L RL Schmidt Edith F EF Ackerson Kate K Kinney Hannah C HC
Acta neuropathologica 20091021 2
Haddad syndrome (congenital central hypoventilation syndrome and Hirschsprung's disease) is a rare disorder for which in-depth neuropathologic analysis is lacking. We report the brain findings in a full-term male infant with Haddad syndrome who died at 27 days of life. Bilateral hypoplasia of the superior temporal lobe and gyral anomalies in the frontal cortex were present. Immunohistochemistry with an antibody to tyrosine hydroxylase (noradrenaline synthesis) demonstrated hypoplasia of the locu ...[more]
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