Ontology highlight
ABSTRACT:
SUBMITTER: Duttmann M
PROVIDER: S-EPMC3274815 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Düttmann Markus M Togashi Yuichi Y Yanagida Toshio T Mikhailov Alexander S AS
Biophysical journal 20120207 3
According to recent experiments, the molecular-motor myosin behaves like a strain sensor, exhibiting different functional responses when loads in opposite directions are applied to its tail. Within an elastic-network model, we explore the sensitivity of the protein to the forces acting on the tail and find, in agreement with experiments, that such forces invoke conformational changes that should affect filament binding and ADP release. Furthermore, conformational responses of myosin to the appli ...[more]