Ontology highlight
ABSTRACT:
SUBMITTER: Tanpure RP
PROVIDER: S-EPMC3275140 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Tanpure Rajendra P RP Nguyen Benson L BL Strecker Tracy E TE Aguirre Savannah S Sharma Suman S Chaplin David J DJ Siim Bronwyn G BG Hamel Ernest E Lippert John W JW Pettit George R GR Trawick Mary Lynn ML Pinney Kevin G KG
Journal of natural products 20110630 7
The natural products combretastatin A-4 (CA4) and combretastatin A-1 (CA1) are potent cancer vascular disrupting agents and inhibitors of tubulin assembly (IC₅₀ = 1-2 μM). The phosphorylated prodrugs CA4P and CA1P are undergoing human clinical trials against cancer. CA1 is unique due to its incorporation of a vicinal phenol, which has afforded the opportunity to prepare both diphosphate and regioisomeric monophosphate derivatives. Here, we describe the first synthetic routes suitable for the reg ...[more]