Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC3275555 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Yu Xinzi X Machesky Laura M LM
PloS one 20120208 2
The ability of tumor cells to invade is one of the hallmarks of the metastatic phenotype. To elucidate the mechanisms by which tumor cells acquire an invasive phenotype, in vitro assays have been developed that mimic the process of cancer cell invasion through basement membrane or in the stroma. We have extended the characterization of the circular invasion assay and found that it provides a simple and amenable system to study cell invasion in matrix in an environment that closely mimics 3D inva ...[more]