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History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium.


ABSTRACT: A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention.We pooled data from 12 case-control studies including 6,448 cases and 13,747 controls, and estimated OR and 95% CI for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, and body mass index.We observed a weak association between diabetes and the incidence of HNC overall (OR, 1.09; 95% CI: 0.95-1.24). However, we observed a modest association among never smokers (OR, 1.59; 95% CI: 1.22-2.07), and no association among ever smokers (OR, 0.96; 95% CI: 0.83-1.11); likelihood ratio test for interaction P = 0.001.A history of diabetes was weakly associated with HNC overall, but we observed evidence of effect modification by smoking status, with a positive association among those who never smoked cigarettes.This study suggests that glucose metabolism abnormalities may be a HNC risk factor in subgroups of the population. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNC risk, possibly providing new strategies in the prevention of HNC.

SUBMITTER: Stott-Miller M 

PROVIDER: S-EPMC3275674 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium.

Stott-Miller Marni M   Chen Chu C   Chuang Shu-Chun SC   Lee Yuan-Chin Amy YC   Boccia Stefania S   Brenner Hermann H   Cadoni Gabriela G   Dal Maso Luigino L   La Vecchia Carlo C   Lazarus Philip P   Levi Fabio F   Matsuo Keitaro K   Morgenstern Hal H   Müller Heiko H   Muscat Joshua J   Olshan Andrew F AF   Purdue Mark P MP   Serraino Diego D   Vaughan Thomas L TL   Zhang Zuo-Feng ZF   Boffetta Paolo P   Hashibe Mia M   Schwartz Stephen M SM  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20111205 2


<h4>Background</h4>A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention.<h4>Methods</h4>We pooled data from 12 case-control studies including 6,448 cases and 13,747 controls, and estimated OR and 95% CI for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, and body mass inde  ...[more]

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