Ontology highlight
ABSTRACT:
SUBMITTER: Honorat M
PROVIDER: S-EPMC3275985 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Honorat Mylène M Mesnier Aurélia A Vendrell Julie J Di Pietro Attilio A Lin Valérie V Dumontet Charles C Cohen Pascale P Payen Léa L
International journal of breast cancer 20110120
The ATP-binding cassette multidrug resistance protein 8 (MRP8/ABCC11) mediates the excretion of anticancer drugs. ABCC11 mRNA and protein levels were enhanced by DEX (dexamethasone) and by PROG (progesterone) in MCF7 (progesterone receptor-(PR-) positive) but not in MDA-MB-231 (PR-negative) breast cancer cells. This suggested a PR-signaling pathway involvement in ABCC11 regulation. Nevertheless, pregnenolone-16α-carbonitrile (GR antagonist) and clotrimazole strongly and moderately decreased ABCC ...[more]