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Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in ?-Amanitin Resistance and/or Reduced Function.

ABSTRACT: Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause ?-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 regions that are essential for development in a multicellular organism.

SUBMITTER: Bowman EA

PROVIDER: S-EPMC3276164 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function.

Bowman Elizabeth Anne EA Riddle Donald L DL Kelly William W

G3 (Bethesda, Md.) 20111101 6

Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause α-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 regions that are essential for development in a multicellular organism. ...[more]

PMID: 22384351

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