Whole genome resequencing reveals natural target site preferences of transposable elements in Drosophila melanogaster.

ABSTRACT: Transposable elements are mobile DNA sequences that integrate into host genomes using diverse mechanisms with varying degrees of target site specificity. While the target site preferences of some engineered transposable elements are well studied, the natural target preferences of most transposable elements are poorly characterized. Using population genomic resequencing data from 166 strains of Drosophila melanogaster, we identified over 8,000 new insertion sites not present in the reference genome sequence that we used to decode the natural target preferences of 22 families of transposable element in this species. We found that terminal inverted repeat transposon and long terminal repeat retrotransposon families present clade-specific target site duplications and target site sequence motif

SUBMITTER: Linheiro RS 

PROVIDER: S-EPMC3276498 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature