Ontology highlight
ABSTRACT:
SUBMITTER: De Gregori S
PROVIDER: S-EPMC3276770 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
De Gregori Simona S De Gregori Manuela M Ranzani Guglielmina Nadia GN Allegri Massimo M Minella Cristina C Regazzi Mario M
Metabolic brain disease 20111224 1
The chemical structures of morphine and its metabolites are closely related to the clinical effects of drugs (analgesia and side-effects) and to their capability to cross the Blood Brain Barrier (BBB). Morphine-6-glucuronide (M6G) and Morphine-3-glucuronide (M3G) are both highly hydrophilic, but only M6G can penetrate the BBB; accordingly, M6G is considered a more attractive analgesic than the parent drug and the M3G. Several hypotheses have been made to explain these differences. In this review ...[more]