Mouse genomic variation and its effect on phenotypes and gene regulation.
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ABSTRACT:
SUBMITTER: Keane TM
PROVIDER: S-EPMC3276836 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Mouse genomic variation and its effect on phenotypes and gene regulation.
Keane Thomas M TM Goodstadt Leo L Danecek Petr P White Michael A MA Wong Kim K Yalcin Binnaz B Heger Andreas A Agam Avigail A Slater Guy G Goodson Martin M Furlotte Nicholas A NA Eskin Eleazar E Nellåker Christoffer C Whitley Helen H Cleak James J Janowitz Deborah D Hernandez-Pliego Polinka P Edwards Andrew A Belgard T Grant TG Oliver Peter L PL McIntyre Rebecca E RE Bhomra Amarjit A Nicod Jérôme J Gan Xiangchao X Yuan Wei W van der Weyden Louise L Steward Charles A CA Bala Sendu S Stalker Jim J Mott Richard R Durbin Richard R Jackson Ian J IJ Czechanski Anne A Guerra-Assunção José Afonso JA Donahue Leah Rae LR Reinholdt Laura G LG Payseur Bret A BA Ponting Chris P CP Birney Ewan E Flint Jonathan J Adams David J DJ
Nature 20110914 7364
We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the ...[more]
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