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Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease.

ABSTRACT: An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.

SUBMITTER: Valente AX

PROVIDER: S-EPMC3277088 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease.

Valente André X C N AX Shin Joo H JH Sarkar Abhijit A Gao Yuan Y

Scientific reports 20120210

An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory. ...[more]

PMID: 22355768

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