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Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.


ABSTRACT: We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

SUBMITTER: Hunder NN 

PROVIDER: S-EPMC3277288 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.

Hunder Naomi N NN   Wallen Herschel H   Cao Jianhong J   Hendricks Deborah W DW   Reilly John Z JZ   Rodmyre Rebecca R   Jungbluth Achim A   Gnjatic Sacha S   Thompson John A JA   Yee Cassian C  

The New England journal of medicine 20080601 25


We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1. ...[more]

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