Ontology highlight
ABSTRACT:
SUBMITTER: Hunder NN
PROVIDER: S-EPMC3277288 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Hunder Naomi N NN Wallen Herschel H Cao Jianhong J Hendricks Deborah W DW Reilly John Z JZ Rodmyre Rebecca R Jungbluth Achim A Gnjatic Sacha S Thompson John A JA Yee Cassian C
The New England journal of medicine 20080601 25
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1. ...[more]