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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.

ABSTRACT: Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-? (sTNF?RII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNF?RII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNF?RII at baseline, and IL-6 and sTNF?RII 25-min poststressor, as well as total output of sTNF?RII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNF?RII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.

SUBMITTER: Chiang JJ

PROVIDER: S-EPMC3277534 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.

Chiang Jessica J JJ Eisenberger Naomi I NI Seeman Teresa E TE Taylor Shelley E SE

Proceedings of the National Academy of Sciences of the United States of America 20120123 6

Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants ...[more]

PMID: 22308464

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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.

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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.

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