Ontology highlight
ABSTRACT:
SUBMITTER: Nishino T
PROVIDER: S-EPMC3277711 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Nishino Tatsuya T Takeuchi Kozo K Gascoigne Karen E KE Suzuki Aussie A Hori Tetsuya T Oyama Takuji T Morikawa Kosuke K Cheeseman Iain M IM Fukagawa Tatsuo T
Cell 20120201 3
The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation. Defining the nature of the DNA-protein interactions that specify the position of the kinetochore and provide a scaffold for kinetochore formation remain key goals. Here, we demonstrate that the centromeric histone-fold-containing CENP-T-W and CENP-S-X complexes coassemble to form a stable CENP-T-W-S-X heterotetramer. High-resolution structural analysis of the indiv ...[more]