Ontology highlight
ABSTRACT:
SUBMITTER: Kur E
PROVIDER: S-EPMC3278082 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Kur Esther E Christa Anna A Veth Kerry N KN Gajera Chandresh R CR Andrade-Navarro Miguel A MA Zhang Jingjing J Willer Jason R JR Gregg Ronald G RG Abdelilah-Seyfried Salim S Bachmann Sebastian S Link Brian A BA Hammes Annette A Willnow Thomas E TE
Developmental dynamics : an official publication of the American Association of Anatomists 20110331 6
Low-density lipoprotein receptor-related protein 2 (LRP2) is a multifunctional cell surface receptor conserved from nematodes to humans. In mammals, it acts as regulator of sonic hedgehog and bone morphogenetic protein pathways in patterning of the embryonic forebrain and as a clearance receptor in the adult kidney. Little is known about activities of this LRP in other phyla. Here, we extend the functional elucidation of LRP2 to zebrafish as a model organism of receptor (dys)function. We demonst ...[more]