Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor CM
PROVIDER: S-EPMC3278154 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
O'Connor Colleen M CM Sheppard Sabina S Hartline Cassie A CA Huls Helen H Johnson Mark M Palla Shana L SL Maiti Sourindra S Ma Wencai W Davis R Eric RE Craig Suzanne S Lee Dean A DA Champlin Richard R Wilson Heather H Cooper Laurence J N LJ
Scientific reports 20120213
Clinical observations reveal that an augmented pace of T-cell recovery after chemotherapy correlates with improved tumor-free survival, suggesting the add-back of T cells after chemotherapy may improve outcomes. To evaluate adoptive immunotherapy treatment for B-lineage non-Hodgkin lymphoma (NHL), we expanded T cells from client-owned canines diagnosed with NHL on artificial antigen presenting cells (aAPC) in the presence of human interleukin (IL)-2 and IL-21. Graded doses of autologous T cells ...[more]