Ontology highlight
ABSTRACT:
SUBMITTER: Ekkati AR
PROVIDER: S-EPMC3278212 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ekkati Anil R AR Bollini Mariela M Domaoal Robert A RA Spasov Krasimir A KA Anderson Karen S KS Jorgensen William L WL
Bioorganic & medicinal chemistry letters 20120105 4
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with computational guidance. Extension of azine-containing inhibitors into the entrance channel between Lys103 and Glu138 has led to the discovery of potent and structurally novel derivatives including dimeric inhibitors in an NNRTI-linker-NNRTI motif. ...[more]