Single-stranded genomic architecture constrains optimal codon usage.
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ABSTRACT:
SUBMITTER: Cardinale DJ
PROVIDER: S-EPMC3278643 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Single-stranded genomic architecture constrains optimal codon usage.
Cardinale Daniel J DJ Duffy Siobain S
Bacteriophage 20110701 4
Viral codon usage is shaped by the conflicting forces of mutational pressure and selection to match host patterns for optimal expression. We examined whether genomic architecture (single- or double-stranded DNA) influences the degree to which bacteriophage codon usage differ from their primary bacterial hosts and each other. While both correlated equally with their hosts' genomic nucleotide content, the coat genes of ssDNA phages were less well adapted than those of dsDNA phages to their hosts' ...[more]
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