Ontology highlight
ABSTRACT:
SUBMITTER: Vilotti S
PROVIDER: S-EPMC3278732 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Vilotti S S Biagioli M M Foti R R Dal Ferro M M Lavina Z Scotto ZS Collavin L L Del Sal G G Zucchelli S S Gustincich S S
Cell death and differentiation 20110916 3
TRAF and TNF receptor-associated protein (TTRAP) is a multifunctional protein that can act in the nucleus as a 5'-tyrosyl DNA phosphodiesterase and in the cytoplasm as a regulator of cell signaling. In this paper we show that in response to proteasome inhibition TTRAP accumulates in nucleolar cavities in a promyelocytic leukemia protein-dependent manner. In the nucleolus, TTRAP contributes to control levels of ribosomal RNA precursor and processing intermediates, and this phenotype is independen ...[more]