Dataset Information

ART: a next-generation sequencing read simulator.

ABSTRACT:

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ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles.

Availability

Both source and binary software packages are available at http://www.niehs.nih.gov/research/resources/software/art.

SUBMITTER: Huang W

PROVIDER: S-EPMC3278762 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Publications

ART: a next-generation sequencing read simulator.

Huang Weichun W Li Leping L Myers Jason R JR Marth Gabor T GT

Bioinformatics (Oxford, England) 20111223 4

<h4>Unlabelled</h4>ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large seque ...[more]

PMID: 22199392

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Dataset Information

ART: a next-generation sequencing read simulator.

Unlabelled

Availability

Publications

ART: a next-generation sequencing read simulator.

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