Ontology highlight
ABSTRACT:
SUBMITTER: Dimova NV
PROVIDER: S-EPMC3278798 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nature cell biology 20120129 2
The anaphase-promoting complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin. Lys 48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradation of cyclin B1. Lys 11-linked ubiquitin chains have been implicated in degradation of APC/C substrates, but the Lys 11-chain-forming E2 UBE2S is not essential for mitotic exit, raising questions ...[more]