Unknown

Dataset Information

0

Urinary estrogen metabolites during a randomized soy trial.


ABSTRACT: One of the hypothesized protective mechanisms of soy against breast cancer involves changes in estrogen metabolism to 2-hydroxy (OH) and 16?-OH estrogens. The current analysis examined the effect of soy foods on the 2:16?-OH E(1) ratio among premenopausal women during a randomized, crossover intervention study; women were stratified by equol producer status, a characteristic thought to enhance the protective effects of soy isoflavones. The study consisted of a high-soy diet with 2 soy food servings/day and a low-soy diet with <3 servings of soy/wk for 6 mo each; estrogen metabolites were measured in 3 overnight urines (baseline and at the end of the low- and high-soy diet) using gas chromatography mass spectrometry for the 82 women who completed the study. Urinary isoflavonoids were assessed by liquid chromatography mass spectrometry. When applying mixed models, the 2:16?-OH E(1) ratio increased (P = 0.05) because of a nonsignificant decrease in 16?-OH E(1) (P = 0.21) at the end of the high-soy diet. Similar nonsignificant increases in the 2:16?-OH E(1) ratio were observed in equol producers (P = 0.13) and nonproducers (P = 0.23). These findings suggest a beneficial influence of soy foods on estrogen metabolism regardless of equol producer status.

SUBMITTER: Morimoto Y 

PROVIDER: S-EPMC3279611 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

altmetric image

Publications

Urinary estrogen metabolites during a randomized soy trial.

Morimoto Yukiko Y   Conroy Shannon M SM   Pagano Ian S IS   Isaki Marissa M   Franke Adrian A AA   Nordt Frank J FJ   Maskarinec Gertraud G  

Nutrition and cancer 20120131 2


One of the hypothesized protective mechanisms of soy against breast cancer involves changes in estrogen metabolism to 2-hydroxy (OH) and 16α-OH estrogens. The current analysis examined the effect of soy foods on the 2:16α-OH E(1) ratio among premenopausal women during a randomized, crossover intervention study; women were stratified by equol producer status, a characteristic thought to enhance the protective effects of soy isoflavones. The study consisted of a high-soy diet with 2 soy food servi  ...[more]

Similar Datasets

| S-EPMC3169755 | biostudies-literature
| S-EPMC4227612 | biostudies-literature
| S-EPMC7236781 | biostudies-literature
| S-EPMC8679875 | biostudies-literature
| S-EPMC3475411 | biostudies-other
| S-EPMC3643002 | biostudies-other
| S-EPMC7882395 | biostudies-literature
| S-EPMC3674291 | biostudies-literature
| S-EPMC4029575 | biostudies-literature
| S-EPMC3559002 | biostudies-literature