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Myelosuppression and infectious complications in children with Down syndrome and acute lymphoblastic leukemia.

ABSTRACT: Children with Down syndrome (DS) bear an increased risk of acute lymphoblastic leukemia (ALL) and treatment complications. We compared blood counts and toxicities in 22 DS and 44 non-DS ALL patients. Patients with DS had deeper, longer neutrophil and monocyte count nadirs; more toxicities (HR 2.0, P?=?0.0005); longer hospitalizations (HR 1.4, P?

SUBMITTER: Rabin KR

PROVIDER: S-EPMC3279631 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Myelosuppression and infectious complications in children with Down syndrome and acute lymphoblastic leukemia.

Rabin Karen R KR Smith Justin J Kozinetz Claudia A CA

Pediatric blood & cancer 20111121 4

Children with Down syndrome (DS) bear an increased risk of acute lymphoblastic leukemia (ALL) and treatment complications. We compared blood counts and toxicities in 22 DS and 44 non-DS ALL patients. Patients with DS had deeper, longer neutrophil and monocyte count nadirs; more toxicities (HR 2.0, P = 0.0005); longer hospitalizations (HR 1.4, P < 0.0001); and more frequent microbiologically documented infections (HR 5.7, P = 0.0019), mucositis (HR 29.0, P = 0.0006), and cellulitis (HR 3.0, P = 0 ...[more]

PMID: 22106003

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