A central role for long non-coding RNA in cancer.
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ABSTRACT:
SUBMITTER: Mitra SA
PROVIDER: S-EPMC3279698 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
A central role for long non-coding RNA in cancer.
Mitra Sheetal A SA Mitra Anirban P AP Triche Timothy J TJ
Frontiers in genetics 20120215
Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct class of ncRNAs in cancer-associated pathways that govern mechanisms such as cell growth, invasion, and metastasis. We also highlight the possibility of using these unique RNAs as diagnostic and prog ...[more]
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