Ontology highlight
ABSTRACT:
SUBMITTER: de Jong JH
PROVIDER: S-EPMC3279738 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
de Jong Joan H JH Rodermond Hans M HM Zimberlin Cheryl D CD Lascano Valeria V De Sousa E Melo Felipe F Richel Dick J DJ Medema Jan Paul JP Vermeulen Louis L
Scientific reports 20120215
The epithelial lining of the intestine is characterized by an immense cellular turn-over ascertaining an extensive regenerative capacity. Multiple reports suggest that besides the local intestinal stem cell pool, circulating cells of bone marrow origin (BMDCs) contribute to this process by fusing with the epithelial lineage. However, the functional relevance of these observations is unknown. In the present study we employ a model system in which we cannot only detect cell fusion but also examine ...[more]