Ontology highlight
ABSTRACT:
SUBMITTER: Maeda T
PROVIDER: S-EPMC3280137 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Maeda Toshinari T García-Contreras Rodolfo R Pu Mingming M Sheng Lili L Garcia Luis Rene LR Tomás Maria M Wood Thomas K TK
The ISME journal 20110915 3
Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for bacterial resistance. Using the opportunistic pathogen Pseudomonas aeruginosa, we demonstrate here that bacterial resistance arises rapidly to the best-characterized compound ...[more]