Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.
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ABSTRACT:
SUBMITTER: Simpson CL
PROVIDER: S-EPMC3280198 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.
Simpson Cory L CL Patel Dipal M DM Green Kathleen J KJ
Nature reviews. Molecular cell biology 20110823 9
To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body's most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the cornified layers, they completely reorganize their adhesive junctions and cytoskeleton. These architectural components are more than just rivets and scaffold ...[more]
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