Computational prediction and molecular characterization of an oomycete effector and the cognate Arabidopsis resistance gene.

ABSTRACT: Hyaloperonospora arabidopsidis (Hpa) is an obligate biotroph oomycete pathogen of the model plant Arabidopsis thaliana and contains a large set of effector proteins that are translocated to the host to exert virulence functions or trigger immune responses. These effectors are characterized by conserved amino-terminal translocation sequences and highly divergent carboxyl-terminal functional domains. The availability of the Hpa genome sequence allowed the computational prediction of effectors and the development of effector delivery systems enabled validation of the predicted effectors in Arabidopsis. In this study, we identified a novel effector ATR39-1 by computational methods, which was found to trigger a resistance response in the Arabidopsis ecotype Weiningen (Wei-0). The allelic varian

SUBMITTER: Goritschnig S 

PROVIDER: S-EPMC3280963 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature