Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.
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ABSTRACT:
SUBMITTER: Soberanes S
PROVIDER: S-EPMC3281276 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.
Soberanes Saul S Gonzalez Angel A Urich Daniela D Chiarella Sergio E SE Radigan Kathryn A KA Osornio-Vargas Alvaro A Joseph Joy J Kalyanaraman Balaraman B Ridge Karen M KM Chandel Navdeep S NS Mutlu Gökhan M GM De Vizcaya-Ruiz Andrea A Budinger G R Scott GR
Scientific reports 20120217
Exposure of human populations to chronically elevated levels of ambient particulate matter air pollution < 2.5 μm in diameter (PM(2.5)) has been associated with an increase in lung cancer incidence. Over 70% of lung cancer cell lines exhibit promoter methylation of the tumor suppressor p16, an epigenetic modification that reduces its expression. We exposed mice to concentrated ambient PM(2.5) via inhalation, 8 hours daily for 3 weeks and exposed primary murine alveolar epithelial cells to daily ...[more]
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