Ontology highlight
ABSTRACT:
SUBMITTER: Soberanes S
PROVIDER: S-EPMC3281276 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Scientific reports 20120217
Exposure of human populations to chronically elevated levels of ambient particulate matter air pollution < 2.5 μm in diameter (PM(2.5)) has been associated with an increase in lung cancer incidence. Over 70% of lung cancer cell lines exhibit promoter methylation of the tumor suppressor p16, an epigenetic modification that reduces its expression. We exposed mice to concentrated ambient PM(2.5) via inhalation, 8 hours daily for 3 weeks and exposed primary murine alveolar epithelial cells to daily ...[more]