Ontology highlight
ABSTRACT:
SUBMITTER: Madsen LW
PROVIDER: S-EPMC3281535 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Madsen Lars Wichmann LW Knauf Jeffrey A JA Gotfredsen Carsten C Pilling Andrew A Sjögren Ingrid I Andersen Søren S Andersen Lene L de Boer Anne Sietske AS Manova Katia K Barlas Afsar A Vundavalli Sushil S Nyborg Niels C Berg NC Knudsen Lotte Bjerre LB Moelck Anne Marie AM Fagin James A JA
Endocrinology 20120110 3
Liraglutide and exenatide are glucagon-like peptide receptor (GLP-1R) agonists used in the treatment of type 2 diabetes. Both molecules have been associated with the development of thyroid C-cell tumors after lifetime exposure in rodents. Previously, it has been reported that these tumors are preceded by increased plasma calcitonin and C-cell hyperplasia. We can now document that the murine C-cell effects are mediated via GLP-1R. Thus, 13 wk of continuous exposure to GLP-1R agonists was associat ...[more]