Ontology highlight
ABSTRACT:
SUBMITTER: Perriches T
PROVIDER: S-EPMC3281669 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Perriches Thibaud T Singleton Martin R MR
The Journal of biological chemistry 20120103 7
We have solved the x-ray structure of the N-terminal half of the yeast kinetochore protein Ndc10 at 1.9 Å resolution. This essential protein is a key constituent of the budding yeast centromere and is essential for the recruitment of the centromeric nucleosome and establishment of the kinetochore. The fold of the protein shows unexpected similarities to the tyrosine recombinase/λ-integrase family of proteins, most notably Cre, with some variation in the relative position of the subdomains. This ...[more]