Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC3281713 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20111213 6
ATG16L1 is an essential component of the autophagasome. The T300A allele of ATG16L1 is associated with the increased susceptibility to Crohn disease. In this study, we identified a novel function of ATG16L1, which suppresses signaling of the pro-inflammatory cytokine IL-1β. Deletion of ATG16L1 in mouse embryonic fibroblasts significantly amplifies IL-1β signal transduction cascades. This amplification is due to elevated p62 levels in ATG16L1-deficient cells. We found that ATG16L1 regulates p62 l ...[more]