Ontology highlight
ABSTRACT:
SUBMITTER: Moon MJ
PROVIDER: S-EPMC3281735 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Moon Mi Jin MJ Kim Hee Young HY Park Sumi S Kim Dong-Kyu DK Cho Eun Bee EB Park Cho Rong CR You Dong-Joo DJ Hwang Jong-Ik JI Kim Kyungjin K Choe Han H Seong Jae Young JY
The Journal of biological chemistry 20111121 6
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play important roles in insulin secretion through their receptors, GLP1R and GIPR. Although GLP-1 and GIP are attractive candidates for treatment of type 2 diabetes and obesity, little is known regarding the molecular interaction of these peptides with the heptahelical core domain of their receptors. These core domains are important not only for specific ligand binding but also for ligand-induced receptor acti ...[more]