Biclustering of adverse drug events in the FDA's spontaneous reporting system.
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ABSTRACT:
SUBMITTER: Harpaz R
PROVIDER: S-EPMC3282185 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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Biclustering of adverse drug events in the FDA's spontaneous reporting system.
Harpaz R R Perez H H Chase H S HS Rabadan R R Hripcsak G G Friedman C C
Clinical pharmacology and therapeutics 20101229 2
In this article, we present a new pharmacovigilance data mining technique based on the biclustering paradigm, which is designed to identify drug groups that share a common set of adverse events (AEs) in the spontaneous reporting system (SRS) of the US Food and Drug Administration (FDA). A taxonomy of biclusters is developed, revealing that a significant number of bona fide adverse drug event (ADE) biclusters have been identified. Statistical tests indicate that it is extremely unlikely that the ...[more]
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